scRNA-seq profiles for 114 individuals, including 66 (58%) with ILD and 48 (42%) unaffected donors. The ILD lungs included samples from 39 individuals with IPF and 27 with other forms of pulmonary fibrosis, including sarcoidosis (n = 4), connective tissue disease-associated ILD (n = 3), idiopathic nonspecific interstitial pneumonia (n = 3), coal worker’s pneumoconiosis (n = 3), chronic hypersensitivity pneumonitis (n = 2), interstitial pneumonia with autoimmune features (n = 2) and unclassifiable ILD (n = 10). Most (67%) the lung samples were from individuals with self-reported ethnicity of European ancestry; 53 (46%) reported past or present tobacco use.