Principal Investigators
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| Gloria Pryhuber, MD, Principal Investigator | Ravi Misra, Ph.D, co-Investigator | Thomas J. Mariani, Ph.D, co-Investigator |
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| Phillip J. Katzman, MD, co-Investigator | Gail H. Deutsch, MD, co-Investigator |
Research Description
In collaboration with: |
National Disease Research Interchange |
International Institute for the Advancement of Medicine |
The research team at the University of Rochester Medical Center has served as the Human Tissue Core (HTC) for LungMAP since the program’s inception in 2014. The BioRepository for INvestigation of Diseases of the Lung (BRINDL) was established to preserve samples collected from predominantly non-diseased pediatric donors in collaboration with organ procurement organizations to obtain material authorized for research when not suitable for transplant. In LungMAP II, we expanded the repository to include pediatric rare diseases including bronchopulmonary dysplasia, children’s interstitial lung disease (chILD), pulmonary hypoplasia and the more common disease, asthma. BRINDL now contains over 480 human, non-fetal, lung sets spanning mid-late gestation to adult age, as well as an additional 90+ with specified disease. Sample has been utilized by approximately 60 investigators and institutions across the world to complete cellular, molecular, and microscopic studies, contributing to over 50 publications. In LungMAP Phase III, the HTC will continue to collect tissue using the established workflow. Because of the concern and complexity in recovering high-quality lungs in a standardized manner and with as little ischemia-induced artifact as possible, and the need to meet all legal and ethical standards, we continue to choose to work primarily through elements of the United Network of Organ Sharing, the federally contracted Organ Procurement and Transplantation Network (OPTN), and two non-profit organizations to whom are referred non-transplantable donated organs suitable for research, The National Disease Research Interchange (NDRI) and the International Institute for the Advancement of Medicine (IIAM). We are also available to Pediatric Pulmonary Centers for referral of rare lung disease samples. In addition, we will assist LungMAP Phase III Research Centers in developing methods to collect and catalog tissue that fall into their disease domain expertise. Cases will include healthy and diseased donors from diverse ethnic and racial backgrounds. The HTC will assist RC teams in collecting detailed metadata for each sample and such information will be included in the BRINDL database. Biospecimens from all phases of LungMAP will be available to qualified LungMAP and non-LungMAP researchers (https://brindl.urmc.rochester.edu), and integrated into the LungMAP Data Coordinating Center’s portal system. Our URMC-HTC, in collaboration with Seattle Children’s Research Institute, will prepare the donated organs and tissues to meet the needs of the LUNGMAP Phase III. Finally, the BRINDL repository will be prepared for long-term access as the LungMAP program sunsets at the end of Phase III.
BRINDL can be accessed from here.
URMC
University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester , NY 14642
