Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease.
Cell reports, Aug 2021
Low Dose Hyperoxia Primes Airways for Fibrosis in Mice after Influenza A Infection.
American journal of physiology. Lung cellular and molecular physiology, 07 2021
A homozygous stop-gain variant in ARHGAP42 is associated with childhood interstitial lung disease, systemic hypertension, and immunological findings.
PLoS genetics, Jul 2021
Surfactant protein C mutation links postnatal type 2 cell dysfunction to adult disease.
JCI insight, Jul 2021
International Analysis of Electronic Health Records of Children and Youth Hospitalized With COVID-19 Infection in 6 Countries.
JAMA network open, 06 2021
VEGF receptor 2 (KDR) protects airways from mucus metaplasia through a Sox9-dependent pathway.
Developmental cell, Jun 2021
CRISPRi-mediated functional analysis of NKX2-1-binding sites in the lung.
Communications biology, 05 2021
Alveolar epithelial cell fate is maintained in a spatially restricted manner to promote lung regeneration after acute injury.
Cell reports, May 2021