• Alveoli

    Alveoli are tiny sacs within lungs that allow oxygen and carbon dioxide to move between the lungs and bloodstream.

  • Anatomy

    The study of the structures of organisms.

  • Anatomical Structures

    The bodily structure of a plant or an animal or of any of its parts.

  • Anatomy Tree

    Anatomical structures from the developing mouse and human lower respiratory tract system and their relationships are displayed as a tree.

  • Annotation

    A note of explanation or comment added to text or diagram.

  • Antigen

    An antigen is any substance that causes the immune system to produce antibodies against it. An antigen may be a foreign substance from the environment, such as chemicals, bacteria, viruses, or pollen. An antigen may also be formed inside the body, as with bacterial toxins or tissue cells.

  • Assay Type

    Analysis done to determine the presence of a substance and the amount of that substance.

  • BREATH

    Bioinformatics REsource ATlas for the Healthy lung is a highly functional, publically accessible platform which facilitates analysis of data generated by LungMAP Research Centers.

  • Bronchus

    A bronchus (plural Bronchi) is a passageway in the respiratory tract that conducts air into the lungs. There is a right bronchus and a left bronchus and these bronchi branch into smaller secondary and tertiary bronchi which branch into smaller tubes, known as bronchioles.

  • Bronchiole

    The bronchioles or bronchioli are the passageways by which air passes through the bronchi to the alveoli (air sacs) of the lungs. They are branches of the bronchi, and are part of the conducting zone of the respiratory system.

  • Cartilage

    Firm, whitish, flexible connective tissue found in various forms in the larynx and respiratory tract, in structures such as the external ear, and in the articulating surfaces of joints.

  • Cell

    The smallest structural and functional unit of an organism, typically microscopic and consisting of cytoplasm and a nucleus enclosed in a membrane.

  • Cytoplasm

    It is the space between the nucleus and the outer cell membrane, which is composed of the cytosol, i.e., a fluid containing water-soluble molecules, and organelles with specific cell functions, such as the mitochondria and endoplasmic reticulum.

  • Distal

    Away from the attachment, origin, or point of reference of the organ or structure.

  • Eukaryotic Cells

    Cells which contain a nucleus and are mainly found in multi-cellular organisms. They also contain organelles which serve a specific job in the cell.

  • Gene

    A gene is a small piece of genetic material, or coded DNA segment that contains within it a set of instructions for making molecules that organisms need to function properly.

  • Gene Expression

    Genes cannot be used directly by an organism. Instead they must be turned into a gene product, i.e., RNA and/or protein. Gene expression is the process by which the information contained within a gene becomes a useful product.

  • Hierarchical Clustering

    Hierarchical clustering involves creating clusters that have a predetermined ordering from top to bottom.

  • Hilum

    Part of an organ where structures such as blood vessels and nerves enter.

  • Hyaline Cartilage

    Translucent bluish-white type of cartilage present in the joints, the respiratory tract, and the immature skeleton.

  • Immunofluorescence

    Immunofluorescence is a powerful technique that utilizes fluorescent-labeled antibodies to detect specific target antigens.

  • ISH

    In situ hybridization (ISH) is a molecular technique used to detect local patterns of gene expression within cells and tissues by assaying the net amounts of mRNA encoded by a specific gene at a given time.

  • Larynx

    The hollow muscular organ forming an air passage to the lungs and holding the vocal cords in humans and other mammals.

  • LungMAP

    The objective of the Molecular Atlas of Lung Development Program (LungMAP) is to develop a molecular atlas of the developing lung from human and mouse to serve as a unique reference resource for the research community.

  • Lymph

    Fluid containing infection-fighting white blood cells, found throughout the body. 

  • Lymphatic System

    Network of tissues and organs that help rid the body of toxins, waste and other unwanted materials. The primary function of the lymphatic system is to transport lymph.

  • Lymphatic Vessel

    Lymphatic vessels are structures of the lymphatic system that transport fluid away from tissues. Lymphatic vessels are similar to blood vessels, but they do not carry blood. The fluid transported by lymphatic vessels is called lymph.

  • Mass Spectrometry

    Mass spectrometry (MS) is an instrumental method for identifying the chemical constitution of a substance by means of the separation of gaseous ions according to their differing mass and charge.

  • Molecular Pathway

    A series of actions among molecules in a cell that leads to a certain end point or cell function.

  • mRNA

    Messenger RNA (mRNA) convey genetic information from DNA to ribosome.

  • Nerve

    A bundle of fibers that uses electrical and chemical signals to transmit sensory and motor information from one body part to another.

  • Nucleus

    Spherical mass of protoplasm encased in double membrane and found in most eukaryotic cells, directing their growth, metabolism, and reproduction, and functioning in the transmission of genic characters. It is the location of the cell's DNA.

  • Omics

    “Omics” refers to the collective technologies used to explore the roles, relationships, and actions of the various types of molecules that make up the cells of an organism. Examples include genomics, proteomics, and lipidomics.

  • Ontology

    An ontology is a description of what exists. It includes entities (things or processes) and their relationships. An anatomy ontology comprises anatomical structures (e.g. lung) and their structural (part-of) and type (is-a) relationships. Some anatomy ontologies, including the LungMAP ontology, also include temporal relationships (exists at stages X to Y). The anatomy ontology facilitates annotation of gene expression patterns by providing standard names for structures. It also facilitates data mining by providing descriptions of the relationships between structures. The LungMAP ontology is a hierarchy of histologically defined anatomical structures for canalicular to alveolar stages in the developing mouse and postnatal human lower respiratory tract system.

  • Organelle

    Organized structure in a cell that performs a specific function.

  • Organism

    An individual living thing that can react to stimuli, reproduce, grow, and maintain homeostasis. It can be a virus, bacterium, protist, fungus, plant or animal.

  • Pathway

    A sequence of chemical reactions undergone by a compound or class of compounds in a living organism.

  • Probe

    Two types of probes are used to generate data for LungMAP: 1) a DNA or RNA hybridization probe used to detect the presence of its complementary nucleotide sequence by binding to that site; and 2) an antibody probe used to detect a specific target protein by binding to its antigenic sites. Subsequent detection or visualization of labeled DNA/RNA and/or antibody binding to their gene products is used to assay gene expression in the tissue, cell, or structure of interest.

  • Proteome

    “Proteome” refers to the entire complement of proteins, including the modifications made to a particular set of proteins, produced by an organism or a cellular system.

  • Proteomics

    Proteomics is a large-scale comprehensive study of a specific proteome, including information on protein abundances, their variations and modifications, along with their interacting partners and networks, in order to understand cellular processes.

  • Protoplasm

    The ground substance of living material and, hence, responsible for all living processes. It contains two major divisions: cytoplasm and nucleoplasm (cell nucleus).

  • Proximal

    Closest to the attachment, origin, or point of reference of the organ or structure.

  • Pleura

    Thin serous membranes enveloping the lungs (visceral pleura) and lining the inner walls of the thoracic cavity (parietal pleura). A thin film of fluid (pleural fluid), secreted into the space (pleural cavity) between these two linings, acts as a lubricant, allowing the membranes to glide smoothly during respiration.

  • Pulmonary Artery

    Artery that carries blood from the right ventricle of the heart to the lungs.

  • Pulmonary Capillary Bed

    Capillaries that are in the lung.

  • Ribosome

    Ribosomes are organelles where proteins are made.

  • RNA

    Ribonucleic acid (RNA) is a transcript of the genetic code found within the nucleus of the cell.

  • RNA-seq

    RNA-seq is a method to quantify, discover and profile RNAs. It produces millions of sequences from complex RNA samples.

  • Trachea

    The tube in humans and other air-breathing vertebrates extending from the larynx to the bronchi, serving as the principal passage for conveying air to and from the lungs; the windpipe.

  • Strain

    The collective descendants of a common ancestor; a race, stock, line, or breed.

  • Standard Deviation

    Measure that is used to quantify the amount of variation or dispersion of a set of data values. A standard deviation close to zero indicates that the data points tend to be very close to the mean.

  • Time Course Experiment

    Time-course experiments require that the levels of different data like proteins and lipids are observed in a cell at different time points over the course of a given time frame.

  • Tissue

    A group or layer of similarly specialized cells that together perform certain specific functions.

  • Type I Pneumocyte

    The cell responsible for the gas (oxygen and carbon dioxide) exchange that takes place in the alveoli.

  • Type II Pneumocyte

    The cell responsible for the production and secretion of surfactant, the molecule that reduces the surface tension of pulmonary fluids and contributes to the elastic properties of the lungs.

  • Visualization Method

    Any one of a variety of detection systems, such as an enzymatic reaction or fluorescent label, used to visualize and then record nucleotide or antibody binding to target gene products in tissues or cells.

  • Z-Score

    A Z-Score is a statistical measurement of a score's relationship to the mean in a group of scores. A Z-score of 0 means the score is the same as the mean. A Z-score can also be positive or negative, indicating whether it is above or below the mean and by how many standard deviations.